Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,506 – 5,520 of 60,541 results

5,506

Medchemexpress LLC Chlormidazole hydrochloride | 74298-63-8 | 99.45% | 5 MG

Chlormidazole hydrochloride is an antifungal agent with inhibitory activity against many fungi and some gram-positive cocci. It can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses.

Antifungal agent.
Inhibits many fungi and some gram-positive cocci.
Applicable in fungal and bacterial infections of nails and skin.

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5,507

Medchemexpress LLC Recombinant human aldehyde dehydrogenase 3A1, His-tagged | >90.0% | 100 UG

Recombinant human aldehyde dehydrogenase 3A1 is a full-length, His-tagged enzyme expressed in Sf9 insect cells and supplied as a PBS solution (pH 7.4). The product is provided as 100 μg of purified protein (~50 kDa, M1-H453) with >90% purity by reducing SDS-PAGE and is intended for research use.

Full-length human sequence (M1-H453).
N-terminal His tag for purification and detection.
Expressed in Sf9 insect cells for eukaryotic processing.
Supplied in PBS, pH 7.4, 0.22 μm filtered.
Purity greater than 90% by reducing SDS-PAGE.
Approximate molecular weight ~50 kDa.
Store at 4°C; stable for 6 months; avoid repeated freeze-thaw cycles.

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5,508

Cayman Chemical EMPO, Purity: ≥95%, CAS: 61856-99-3, 50 mg

A hydrophilic cyclic nitrone free radical spin trap; EMPO-superoxide adduct that exhibits a t1/2 of 4.8 minutes

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5,509

Cayman Chemical Etonogestrel, Purity: ≥98%, CAS: 54048-10-1, 5 mg

A progesterone and androgen receptor antagonist (IC50s = 0.51 and 0.12 nM for isolated rabbit uterus and rat prostate cells, respectively) and an active metabolite of desogestrel; increases endometrial and myometrial vascularization, uterine weight, and uterine artery length, as well as decreases the number of hormone-secreting corpus luteal glands in non-ovariectomized guinea pigs when administered subcutaneously as a 1 mm sustained-release pellet

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5,510

Cayman Chemical GSK2292767, Purity: ≥98%, CAS: 1254036-66-2, 10 mg

A potent and selective inhibitor of PI3Kδ (Ki = 79 pM); has >1,000-fold selectivity for PI3Kδ over isoforms PI3Kα, PI3Kβ, and PI3Kγ (Kis = 501, 630, and 501 nM, respectively); >100-fold selective for PI3Kδ over a panel of 250 kinases; inhibits IFNγ and IL-2 production (IC50s = 1.9 and 3.16 nM, respectively) in a human lung parenchyma assay; protects against eosinophil recruitment (ED50 = 35 μg/kg) in the brown Norway rat acute ovalbumin model of Th2-driven lung inflammation

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5,511

Cayman Chemical PF-05175157, Purity: ≥98%, CAS: 1301214-47-0, 5 mg

An inhibitor of ACC1 and 2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively); inhibits formation of malonyl-CoA in primary rat hepatocytes (EC50 = 29.9 nM); inhibits formation of malonyl-CoA in the liver and skeletal muscle, inhibits hepatic de novo lipogenesis, and lowers the respiratory exchange rate in rats (ED50s = 6, 11, 7.8, and 3.5 mg/kg, respectively)

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5,512

Medchemexpress LLC N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide | 330942-05-7 | MFCD16038040 | >=98.0% | 451.91 | C23H22ClN5O3 | 1 ML

Betrixaban is a potent, selective factor Xa inhibitor used as a research reagent for anticoagulation studies. The compound is characterized by a reported IC50 of 1.5 nM against factor Xa and a molecular weight of 451.91; it is typically handled as a research-grade small molecule and dissolved in DMSO for stock preparations.

Potent factor Xa inhibitor with reported IC50 of 1.5 nM.
Research-grade small molecule for in vitro and in vivo studies.
Molecular formula C23H22ClN5O3 and molecular weight 451.91.
Recommended solvent for stocks: DMSO; example preparations provided for 10 mM solutions.
Storage: powder at -20 °C (long term) or 4 °C (short term); in solvent at -80 °C or -20 °C depending on duration.

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5,513

TARGETMOL CHEMICALS INC OLEANDRIN 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Oleandrin (Folinerin) the principal cardiac glycoside component of PBI-524 can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na K-ATPase pump resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50 8.25 nM) causes an autophagic cell death and altered ERK phosphorylation in undifferentiated. purity: 99%

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5,514

Cayman Chemical 1,2-Dilinoleoyl-3-Stearoyl-rac-glycerol, Purity: ≥98%, CAS: 2190-17-2, 5 mg

A triacylglycerol; has been found in various plant oils

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5,515

Cayman Chemical MKT-077, Purity: ≥95%, CAS: 147366-41-4, 25 mg

A cationic rhodacyanine dye that inhibits the Hsp70 family of chaperones; demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to abrogate the interaction of the chaperone with the tumor suppressor p53

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5,516

Cayman Chemical Imisopasem Manganese, Purity: ≥95%, CAS: 218791-21-0, 5 mg

A SOD mimetic; catalyzes dismutation of the superoxide anion with a catalytic rate constant of >2 x 107 M-1s-1; reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α, IL-1β, and LDH in rats at 1-10 mg/kg, i.v. bolus; inhibits increases in lung and ileum MPO levels, indicating reduced neutrophil infiltration, and increases in plasma MDA, TNF-α, and IL-1β levels in a rat model of ischemia-reperfusion injury and shock induced by SAO at 0.1, 0.3, and 1 mg/kg

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5,517

Cayman Chemical Suprafenacine, Purity: ≥98%, CAS: 1477482-50-0, 5 mg

An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg

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5,518

Cayman Chemical MD2-IN-1, Purity: ≥98%, CAS: 111797-22-9, 5 mg

A chalcone derivative and an inhibitor of the MD-2-LPS interaction; inhibits the interaction between MD-2 and LPS in a cell-free assay at 0.1 µM; inhibits LPS-induced increases in the levels of Tnf-α and Il-6 secreted from isolated and washed MPMs (IC50s = 4.27 and 2.09 µM, respectively); inhibits LPS-induced Nf-κB DNA binding in MPMs at 5 and 20 µM; inhibits the growth of various cancer cells (GI50s = 0.019-0.32 µM, respectively); reduces tumor volume and weight in a HeLa cervical mouse xenograft model at 10 mg/kg for three days; prevents LPS-induced increases in BALF total protein levels and CD68+ macrophage and neutrophil infiltration in a mouse model of LPS-induced acute lung injury at 20 mg/kg per day; reduces MPO activity in isolated neutrophils in the same model

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5,519

TARGETMOL CHEMICALS INC K-RAS-IN-1 5MG

Also available in 1mg 2mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. K-Ras-IN-1 is a K-Ras inhibitor. purity: 98%

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5,520

Medchemexpress LLC Neostigmine methyl sulfate (standard) | 51-60-5 | 98.9% | 25 MG

Neostigmine methyl sulfate (Standard) is an analytical standard of Neostigmine (methyl sulfate) intended for research and analytical applications. It is commonly used in qualitative, quantitative, and methodological research experiments.

Application: Analytical standard for research and analytical applications.
Usage: Commonly employed in qualitative, quantitative, and methodological research experiments.
Techniques: Suitable for HPLC, GC, and MS.

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Bioactive Small Molecules

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Medchemexpress LLC Chlormidazole hydrochloride | 74298-63-8 | 99.45% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Recombinant human aldehyde dehydrogenase 3A1, His-tagged | >90.0% | 100 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide | 330942-05-7 | MFCD16038040 | >=98.0% | 451.91 | C23H22ClN5O3 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Neostigmine methyl sulfate (standard) | 51-60-5 | 98.9% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Chlormidazole hydrochloride | 74298-63-8 | 99.45% | 5 MG

Medchemexpress LLC Recombinant human aldehyde dehydrogenase 3A1, His-tagged | >90.0% | 100 UG

Medchemexpress LLC N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide | 330942-05-7 | MFCD16038040 | >=98.0% | 451.91 | C23H22ClN5O3 | 1 ML

Medchemexpress LLC Neostigmine methyl sulfate (standard) | 51-60-5 | 98.9% | 25 MG